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Categories of FDH mutants
| Class 1: Low expression (presumed protein stability mutant) | Class 2: Expression but low activity (mutations primarily affect MBOAT activity) | Class 3: Nearly normal specific activity (reference) |
|---|---|---|
| G60R | V258E | S136F (44) |
| G168R | S297L | L331R (46) |
| Δ349–355 | H341Y | L347P (45) |
| Δ355–360 | W439X | E361V (47) |
| R365Q | W448X | A369V (45) |
| A374P (45) | ||
| C385R (44) | ||
| W439R (44) |
