TABLE 3.
Compared multifunctionality of various WH2 domains in single module or tandem repeats in actin assembly
Symbols used are as follows: +, −, and ? indicate that the property has been observed, not observed, or not tested, respectively.
| Protein (WH2 no.) | G-actin (ATP, ADP) sequestration | Barbed end elongation | Filament nucleation | Filament severing | Barbed end capping | Barbed end tracking |
|---|---|---|---|---|---|---|
| N-WASP (2) | − | + | − | − | − | + |
| ActA (1) | − | + | − | − | − | − |
| VASP (1) | − | + | + | − | − | + |
| INF2 (1 + FH2) | − | ? | + | + | ? | ? |
| Spire (4) | + (ATP, ADP) | − | + | + | + | − |
| Cordon-Bleu (3) | + (ADP) | + | + | + | − | − |