Table 1.
Major brain activations in 32 pain non-human animal studies
|
Rank order: Pain (32 studies) | ||
|---|---|---|
| Area | Studies reporting activation | Percentage |
| Cingulate |
15 |
47% |
| Thal |
14 |
44% |
| Sens |
13 |
41% |
| Hyp |
12 |
38% |
| Amyg |
9 |
28% |
| PAG |
9 |
28% |
| DS |
9 |
28% |
| Motor |
7 |
22% |
| Ins |
7 |
22% |
| Hipp/parahipp |
6 |
19% |
| NTS |
5 |
16% |
| IC |
5 |
16% |
| LC, PBN, Pretectal area, SC, Septal area |
4 each |
13% |
| Hab, NAc, Raphe, Piriform, PFC(IL/PL)/OFC, Visual ctx |
3 each |
9% |
| Aud ctx, BNST, Cerebellum, Retrosplenial |
2 each |
6% |
| Red n | 1 | 3% |
Results are ordered by the number of studies reporting specific activations; percent of studies reporting activations is used for comparative illustration. For individual study details and inter-study comparisons, see Additional file 1: Table S2A.