Figure 7.
Comparison of the host's adaptive antiviral immune responses between in vivo administration of Synco-2D and Synco-B18R. Immune-competent B6 mice were inoculated systemically with 5 × 107 pfu of Synco-2D (closed circles) or Synco-B18R (closed squares). (a) Blood was collected at the indicated time for quantitative measurement of HSV-specific antibody. (b) For measuring cell-mediated anti-HSV immunity, mice were euthanized at day 7 after virus administration and splenocytes were prepared to lyse syngeneic Panc02 tumor cells that had been infected with UV-inactivated HSV-1. HSV, herpes simplex virus; OD, optical density; pfu, plaque-forming unit.