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. 2012 Aug 7;20(10):1924–1931. doi: 10.1038/mt.2012.133

Figure 1.

Figure 1

Prevention of antibody (Ab) formation by anti-CD3 Abs in wild-type mice. Anti-rhGAA Ab formation as a result of four doses of recombinant human α-glucosidase (rhGAA) was significantly reduced by anti-CD3 Abs in (a) wild-type BALB/c (P = 0.0034) and (b) C57BL/6 mice (P = 0.0002). In BALB/c mice, Ab formation due to a second challenge of rhGAA was also significantly lower in the anti-CD3 Ab-administered group (P =0.0061). (c) “Pre” refers to the initial day of rhGAA administration. “Post” refers to 1 week after the final administration of rhGAA. The individual Ab values are shown as mean values and SEM.