Skip to main content
. 2012 Aug 7;20(10):1924–1931. doi: 10.1038/mt.2012.133

Figure 3.

Figure 3

Prevention of the lethal hypersensitivity reaction and antibody (Ab) titers in Pompe disease (PD) mice. PD mice that were administered repeated doses of recombinant human α-glucosidase (rhGAA) usually died as a result of a lethal hypersensitivity reaction. The immunization schedule is shown in (a). The PD mice that received anti-CD3 Abs survived for a longer period than the hamster immunoglobulin G (IgG)-treated group (log-rank test, P = 0.0002) (b). “0” refers to the initial day of rhGAA administration.