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Titers of Abs against recombinant human α-glucosidase (rhGAA) following the repeated administration of rhGAA in individual Pompe disease (PD) mice. The antibody (Ab) titers of individual mice that received rhGAA repeatedly are shown. The Ab titers of the hamster group are shown in (a) and those of the anti-CD3 Ab group are shown in (b). “0” refers to the initial day of rhGAA administration.
