Figure 5.

The effect of anti-CD3 antibodies (Abs) on effector T cells and regulatory T cells in the spleen. The lymphocyte population in the spleen from mice that received hamster immunoglobulin G (IgG) or anti-CD3 Abs is shown. The anti-CD3 Abs significantly reduced the number of (a) CD4⁺ and (b) CD8⁺ cells and increased the ratio of (c) CD4⁺CD25⁺/CD4⁺ and (d) CD4⁺CD25⁺FoxP3⁺/CD4⁺ cells.