Figure 6.

Effect of anti-CD3 Abs on the number of CD4⁺ and CD8⁺ cells in the peripheral blood. The levels of (a) CD4⁺ and (b) CD8⁺ cells in peripheral blood from mice that received hamster immunoglobulin G (IgG) or anti-CD3 Abs are shown. The administration of anti-CD3 Abs for five consecutive days reduced the levels of CD4⁺ and CD8⁺ cells in the peripheral blood at various time points for up to 36 days after the initiation of anti-CD3 antibody (Ab) or hamster IgG treatment. “0” refers to the initial day of anti-CD3 Abs or hamster IgG administration. *Significant difference between the two groups and “NS” indicates no significant difference between the two groups.