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. 2012 Jun 7;7:34. doi: 10.1186/1750-1172-7-34

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Copyright ©2012 Muto et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Organogenesis requiringSp6 activity. A. Whiskers of rats at postnatal day 1. Each Sp6 genotype in the 1st backcrossed generation was examined. (Wt/Ami, n = 13; Ami/Ami, n = 21) B. Whiskers of adult rats. WT and AMI rats were examined when they were 6–8 months old (WT, n = 3; AMI, n = 14) C. X-ray analysis of the maxillae (Max) and mandibles (Man) of WT (1, 2) and AMI (3, 4) rats. Molars (1, 3) and incisors (2, 4) are highlighted (WT, n = 2; AMI, n = 2) D. Normal number of digits in AMI rats. Digits of the left (1, 3) and right (2, 4) limbs of WT (1, 2) and AMI (3, 4) rats are shown. Upper panels, forelimb; lower panels, hindlimb (WT, n = 3; AMI, n = 14).