Table 2.
Haematology, blood chemistry and parasitology findings of study subjects on enrolment by the study drug
| Parameter | Artemisinin- naphthoquine (AN) | Dihydroartemisinin- piperaquine (DHP) | P | Overall |
|---|---|---|---|---|
|
Number of subjects |
201 |
200 |
|
401 |
|
Haematocrit: mean ± SD (range)% |
36.1 ± 7.1 (15.5–68.9) |
36.6 ± 6.6 (19.1–63.4) |
0.46 |
36.4 ± 6.8 (15.5–68.9) |
|
Haemoglobin: mean ± SD (range) g/dL |
12.5 ± 2.3 (6.2–23.1) |
12.6 ± 2.1 (6.6–21.1) |
0.67 |
12.6 ± 2.2 (6.2–23.1) |
|
Red Blood Cell: mean ± SD (range) per uL |
4.5 ± 0.8 (1.5–7.7) |
4.4 ± 0.8 (2.2–7.3) |
0.70 |
4.4 ± 0.8 (1.5–7.7) |
|
Platelet: mean ± SD (range) 10
3
/mm
3
|
116.4 ± 68.7 (1.8–381.0) |
116.5 ± 65.9 (1 .0–601.0) |
0.98 |
116 ± 67.2 (1.0–601.0) |
|
White Blood Cell: mean ± SD (range) per uL |
6.4 ± 2.2 (2.0–14.0) |
7.1 ± 6.0 (2.2–65.0) |
0.11 |
6.8 ± 4.5 (2.0–65.0) |
|
Bilirubin: mean ± SD (range) mg/dL |
1.0 ± 0.6 (0.1–5.2) |
1.0 ± 0.5 (0.1–3.8) |
0.67 |
1.0 ± 0.5 (0.1–5.2) |
|
Albumin: mean ± SD (range) g/dL |
4.1 ± 1.0 (2.0–7.4) |
4.2 ± 1.0 (2.2–6.2) |
0.25 |
4.2 ± 1.0 (2.1–7.4) |
|
ALT (SGPT): mean ± SD (range) IU/L |
28.8 ± 13.0 (5–73) |
28.3 ± 14.2 (6.9–98.0) |
0.71 |
28.5 ± 13.9 (5.0–98.0) |
|
AST (SGOT): mean ± SD (range) IU/L |
29.4 ± 14.0 (2.0–87.0) |
28.5 ± 11.8 (2.6–91.0) |
0.49 |
28.9 ± 12.9 (2.0–91.0) |
|
Creatinine: mean ± SD (range) mg/dL |
1.0 ± 0.4 (0.2–2.5) |
0.9 ± 0.3 (0.2–2.0) |
0.15 |
0.9 ± 0.4 (0.2–2.5) |
|
Urea: mean ± SD (range) mg/dL |
27.5 ± 11.7 (2.7–80.0) |
27.6 ± 11.7 (8.6–110.0) |
0.94 |
27.6 ± 11.7 (2.7–110.0) |
|
Density of asexual parasites: geometric mean (range) per uL |
6310 (304–113550) |
6972 (372–140084) |
0.21 |
6634 (304–140084) |
|
Gametocyte carriages (%) |
134 (67.3) |
140 (70.3) |
0.54 |
274 (68.8) |
| Density of gametocytes: geometric mean (range) per uL | 40 (1–2697) | 35 (2–2208) | 0.55 | 38 (1–2697) |