Table 4.

PCR corrected efficacy of AN vs Duocotecxin in all malaria, Indonesia

Outcome	Artemisinin- naphthoquine (AN)	Dihydroartemisinin-piperaquine (DHP)	P	Overall
ACPR/Treatment Success (%, 95% CL)
ITT	181 [90.0 (85.9–94.2)]	180 [90.0 (85.8–94.2)]	0.99	361 [90.0 (86.7–92.8)]
Modified ITT	181 [93.3 (89.8–96.8)]	180 [94.7 (91.6–97.9)]	0.55	361 [94.0 (91.1–96.2)]
Per Protocol	181 [96.3 (93.6–99.0)]	180 [97.3 (95.0–99.6)]	0.58	361 [96.8 (94.4–98.3)]
Late Clinical Failure-LCF (%, 95% CL)
ITT	4 [2.0 (0.1–3.9)]	1 [0.5 (0.5–1.5)]	0.18	5 [1.2 (0.4–2.9)]
Modified ITT	4 [2.1 (0.1–4.1)]	1 [0.5 (0.5–1.6)]	0.18	5 [1.3 (0.4–3.0)]
3. Per Protocol	4 [2.1 (0.1–4.2)]	1 [0.5 (0.5–1.6)]	0.18	5 [1.3 (0.4–3.1)]
Late Parasitological Failure-LPF (%, 95% CL)
ITT	3 [1.5 (0.2–3.2)]	4 [2.0 (0.1–3.9)]	0.70	7 [1.7 (0.7–3.6)]
Modified ITT	3 [1.6 (0.2–3.3)]	4 [2.1 (0.1–4.1)]	0.68	7 [1.8 (0.7–3.7)]
Per Protocol	3 [1.6 (0.2–3.4)]	4 [2.2 (0.1–4.3)]	0.69	7 [1.9 (0.8–3.8)]
“Other Failures” (%, 95% CL)
ITT	13 [6.5 (3.1–9.9)]	15 [7.5 (3.8–11.1)]	0.68	28 [7.0 (4.7–9.9)]
Modified ITT	6 [3.1 (0.7–5.5)]	5[2.6 (0.4–4.9)]		11 [2.9 (1.4–5.1)]
Per Protocol	0	0	0.79	0

All protocol violations, withdrawn consents, and lost to follow up were classified as “other failures” in ITT analysis.

All protocol violations and withdrawn consents were classified as “other failures” in modified ITT analysis. PCR corrected was carried out only for P.falciparum recurrences.