Table 1.

Overview of studies on MS risk in children of MS patients

Author	Year	Country	Number of patients	Estimated lifetime risk in general population (%)	Male MS patients				Female MS patients
					Age-adjusted risk for children		Relative risk for children		Age-adjusted risk for children		Relative risk for children
Nielsen et al. [20]	2005	Denmark	8205	Men, 0.3; women, 0.5	-		Daughter	7.5	-		Daughter	4.5
							Son	7.5			Son	9.5
							Total	7.5			Total	6.3
Prokopenko et al. [23]	2003	Italy (Sardinia)	313	0.157	-		-		Total	3.19	Total	20.3
Carton et al. [22]	1997	Belgium	674	0.175	Total	1.51	Total	8.6	Total	1.87	Total	10.7
Robertson et al. [21]	1996	UK	674	0.3 (men, 0.13; women, 0.66)	Daughter	7.12	Daughter	10.8	Daughter	1.74	Daughter	2.6
					Son	2.54	Son	19.5	Son	0.0	Son	0.0
					Total	4.91	Total	16.4	Total	0.81	Total	2.7
Sadovnick and Baird [24]	1988	Canada	815	0.1	Daughter	5.13	Daughter	51.3	Daughter	4.96	Daughter	49.6
					Son	0.0	Son	0.0	Son	0.0	Son	0.0
					Total	2.47	Total	24.7	Total	2.58	Total	25.8