Table 2. Cox regression analysis: predictors of liver recurrence-free survival and overall survival.

Variable	Univariable analysis		Multivariable analysis
	HR (95% CI)	P	HR (95% CI)	P
Liver recurrence-free survival
Positive CXCR4	2.43 (1.31–4.52)	0.005	2.22 (1.15–4.30)	0.018
Male	2.09 (1.01–4.31)	0.046	1.93 (0.90–4.15)	0.094
Age >60 years	0.65 (0.35–1.19)	0.161	0.61 (0.33–1.12)	0.112
pT3 vs. pT1/pT2	2.28 (0.70–7.40)	0.171	—	—
pN1	2.06 (1.05–4.04)	0.037	1.39 (0.67–2.90)	0.379
Tumor size >2 cm	1.12 (0.52–2.43)	0.770	—	—
Moderate/poor grade	1.36 (0.57–3.25)	0.492	—	—
Lymphovascular invasion	1.74 (0.89–3.41)	0.105	—	—
Perineural invasion	1.00 (0.49–2.03)	0.997	—	—
Adjuvant chemotherapy	1.94 (0.97–3.87)	0.061	—	—
Overall survival
Positive CXCR4	2.35 (1.41–3.92)	0.001	1.78 (1.02–3.09)	0.041
Male	1.57 (0.91–2.70)	0.103	—	—
Age >60 years	0.90 (0.54–1.50)	0.694	—	—
pT3 vs. pT1/pT2	2.40 (0.87–6.64)	0.091	—	—
pN1	2.20 (1.27–3.84)	0.005	2.33 (1.27–4.28)	0.007
Tumor size >2 cm	1.94 (0.95–3.95)	0.069	—	—
Moderate/poor grade	1.97 (0.92–4.23)	0.082	2.83 (1.24–6.45)	0.014
Lymphovascular invasion	1.31 (0.77–2.23)	0.313	—	—
Perineural invasion	1.01 (0.56–1.84)	0.963	—	—
Adjuvant chemotherapy	1.31 (0.71–2.43)	0.390	—	—

CI, confidence interval; HR, hazard ratio.