Table 2. Conditional analysis on the SNPs most significantly associated with CRC in TERT–CLPTM1L after imputation.
| SNP | Main effect P -value | r 2 With rs2736100 | Conditioned on rs2736100 P -value | r 2 With rs2853668 | Conditioned on rs2853668 P -value |
|---|---|---|---|---|---|
| rs2736100 | 0.0002 | 1 (ref) | 1 (ref) | 0.15 | 0.001 |
| rs2736122 | 0.001 | 0.20 | 0.01 | 0.00 | 0.003 |
| rs4583925 | 0.002 | 0.03 | 0.01 | 0.00 | 0.004 |
| rs4507531 | 0.003 | 0.03 | 0.02 | 0.00 | 0.004 |
| rs79323805 | 0.003 | 0.03 | 0.02 | 0.00 | 0.005 |
| rs4075202 | 0.005 | 0.03 | 0.03 | 0.00 | 0.008 |
| rs35595862 | 0.03 | 0.00 | 0.01 | 0.05 | 0.07 |
| rs2853668 | 0.06 | 0.15 | 0.50 | 1 (ref) | 1 (ref) |
Abbreviations: CRC=colorectal cancer; ref=reference; SNP=single-nucleotide polymorphism.
The eight most significant SNPs for association using the Mantel–Haenszel method for combining study data are shown, with P-values for an initial unconditioned additive test, and then after conditioning on rs2736100 and rs2853668, respectively.