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Serum AST and ALT after METH treatment. A, B, Rats were treated with METH (10 mg/kg, i.p., every 2 h × 4) or saline (1 ml/kg, i.p., every 2 h × 4). At 2 h after the last injection of METH or saline, (A) ALT and (B) AST levels were significantly elevated to 54.9 ± 15.2% and 141.0 ± 44.1% in METH-treated rats compared with saline controls, respectively. Values are mean ± SEM, *p < 0.05 (n = 12 rats per group).
