Figure 5.

Hyperthermia after METH treatment. Rats were treated with METH (10 mg/kg, i.p., every 2 h × 4) or saline (1 ml/kg, i.p., every 2 h × 4) and lactulose (5.3 g/kg, p.o., every 12 h) or vehicle (8 ml/kg, p.o., every 12 h). During drug treatment, temperature was measured 1 h after each METH injection (denoted by arrows). METH treatment caused significant hyperthermia in both vehicle plus METH-treated and lactulose plus METH-treated rats, and lactulose had no significant effect on hyperthermia (*p < 0.001 compared with Veh Sal) (n = 6–9 per group). Lac, lactulose; Sal, saline; Veh, vehicle.