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. 2012 Jul 20;12:92. doi: 10.1186/1471-230X-12-92

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Copyright ©2012 Invernizzi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Representative analysis of liver tissue sections. Portal and periportal cellular inflammation: lymphocytes, monocytes/macrophages and plasma cells infiltrate the portal tracts and invade the surrounding parenchyma, resulting in the characteristic picture of interface hepatitis. (A) Enlarged portal tracts fields with fibrosis and marked bile ductular proliferation, severe inflammatory biliary tract damage; liver cells showing moderate microvescicular steatosis (H&E, 20X); (B) high-power view of an expanded portal tract field with moderate mixed inflammatory infiltrate and some features of flogistic bile duct damage (H&E, 40X). (C and D) Immunohistology for biliary type cytokeratin 7 shows marked ductular proliferation in portal tracts fields and biliary metaplasia (abnormal positivity to cytokeratin 7) of peri-portal hepatocytes (40 X).