Figure 6.  .

Improved ERG responses 1 month after 5-week-old Lrat^−/− mice received an intravitreal injection of 9-cis-R-Ac in PLGA microparticles. For the intravitreal injection group, 9-cis-R-Ac in microparticles was injected into Lrat^−/− mouse eyes as a single dose of 0.06 mg per each eye (n = 9). For the vehicle group, PLGA microparticles lacking retinoids were intravitreally injected into each Lrat^−/− mouse eye instead (n = 5). (A) Representative ERG traces from 9-cis-R-Ac/microparticle−treated, vehicle-treated, and uninjected control animals. Data are presented as means ± SDs. The control group of Lrat^−/− mice received no injections (n = 5). (B, C) a- and b-wave amplitudes, respectively.