Table 1.

The performance scores for each of the phoshoproteins predicted by the teams and assessed in the DREAM4 phosphoproteomics challenge. The blue entries are the most significant predictions, with P values (PVAL) smaller than 10⁻¹⁰. The red entries are the least significant, with P values larger than 0.01. The overall score is computed as the prediction score (defined as minus the log to the base 10 of the geometric mean of the phosphoprotein P values), minus a penalty that scales with the number of edges in the predicted HepG2 networks (Eq. 3).

Team	Overall score	Edge count	Prediction score	Akt PVAL	ERK1/2 PVAL	IκB PVAL	JNK PVAL	p38 PVAL	HSP27 PVAL	MEK1 PVAL
Team 1	6.68	18	8.17	4.70E–5	1.60E–09	3.80E–10	1.70E–10	1.10E–08	8.30E–11	1.60E–07
Team 2	6.32	17	7.73	9.40E–4	3.50E–14	6.00E–09	1.30E–10	1.40E–10	5.40E–06	4.00E–05
Team 3	6.28	26	8.43	2.10E–5	1.90E–16	3.80E–10	3.80E–10	1.90E–06	1.90E–06	4.90E–09
Team 4	5.02	18	6.51	7.80E–4	1.10E–08	1.30E–08	5.30E–11	4.80E–05	9.30E–07	1.10E–06
Team 5	4.69	17	6.09	3.30E–5	5.90E–11	1.00E–07	2.30E–04	1.10E–05	1.20E–08	3.70E–05
Team 6	4.58	22	6.4	6.80E–5	2.80E–08	1.10E–09	7.30E–11	1.70E–04	2.60E–04	2.40E–07
Team 7	3.72	15	4.96	2.50E–6	8.20E–10	2.30E–04	4.80E–05	2.60E–02	6.60E–03	4.90E–09
Team 8	3.1	27	5.33	1.80E–4	1.50E–05	2.60E–07	6.90E–10	1.30E–04	4.40E–04	1.70E–06
Team 9	2.21	18	3.7	9.40E–4	2.10E–07	4.10E–05	1.20E–04	2.00E–02	2.20E–04	3.10E–03
Team 10	1.55	10	2.37	1.10E–3	1.80E–05	1.50E–02	1.30E–03	5.00E–03	4.90E–02	2.60E–01
Team 11	0.4	19	1.97	6.80E–4	8.50E–01	9.80E–05	1.00E+00	2.30E–03	1.30E–03	8.90E–02
Team 12	0	54	4.47	1.00E–3	6.10E–08	3.60E–04	3.80E–11	1.30E–03	4.10E–03	1.20E–02