Table 2.
Frequency of use of original and additional direct interactions used by the teams to create the model networks. The left side of each set represents the interaction and the right side represents the number of teams using that interaction.
| ORIGINAL INTERACTIONS | ADDED INTERACTIONS | ||
|---|---|---|---|
| TGFα→MEK1 | 12 | IL1α→MEK1 | 9 |
| IKK→IKB | 12 | IL1α→ERK1 | 4 |
| IL1α→JNK | 12 | P38→MEK1 | 2 |
| IL1α→ p38 | 12 | AKT→ JNK | 2 |
| P13K→AKT | 11 | IKK→ERK1/2 | 2 |
| p38→HSP27 | 11 | MEK1→AKT | 1 |
| MEK1→ERK1/2 | 10 | JNK→AKT | 1 |
| TGFα→PI3K | 7 | JNK→IKB | 1 |
| IGF1→MEK1 | 7 | p38→AKT | 1 |
| TNFα→p38 | 7 | IKB→HSP27 | 1 |
| IL1A→IKK | 7 | JNK→MEK1 | 1 |
| TGFα→p38 | 7 | ERK1/2→MEK1 | 1 |
| IGF1→PI3K | 7 | IKK→PI3K | 1 |
| TNFα→IKK | 6 | IKB→ERK1/2 | 1 |
| IL1α→HSP27 | 6 | IKK→HSP27 | 1 |
| AKT→MEK1 | 6 | HSP27→ERK1/2 | 1 |
| TNFα→JNK | 5 | MEK1→JNK | 1 |
| TNFα→PI3K | 4 | IKB→AKT | 1 |
| AKT→IKK | 3 | ||
| TGFα→JNK | 3 | ||
| PI3K→MEK1 | 3 | ||
| IGF1→p38 | 3 | ||
| ERK1/2→HSP27 | 2 | ||
| TGFα→IKK | 2 | ||
| TNFα→HSP27 | 1 | ||