Table 5.

Probabilities that observed mutations occur early^a or late^a for colorectal tumors (Wood et al., 2007)

Gene	Early (90% CI)	Late (90% CI)
ADAMTS18	1 (0.21–1)	0 (0–0.8)
ADAMTSL3	0.46 (0–1)	0.57 (0–1)
APC	0.98 (0.95–1)	0.29 (0–0.6)
C10orf137	0 (0–0)	1 (1–1)
EPHA3	0.17 (0–0.8)	0.87 (0.2–1)
EPHB6	1 (0–1)	0 (0–1)
FBXW7	0.06 (0–0.15)	0.97 (0.9–1)
GNAS	1 (1–1)	0 (0–1)
GUCY1A2	1 (1–1)	0 (0–0.9)
KRAS	0.28 (0.17–1)	0.93 (0–0.98)
MAP2K7	1 (0.3–1)	0 (0–0.73)
MMP2	0.08 (0–0.75)	0.93 (0.25–1)
NAV3	0.39 (0.03–1)	0.63 (0–0.98)
OR51E1	0 (0–0.14)	1 (1–1)
PIK3CA	0.28 (0.04–0.53)	0.87 (0.64–0.99)
PTEN	1 (0–1)	0 (0–1)
RET	0.04 (0–1)	0.97 (0–1)
SEC8L1	0 (0–0.03)	1 (1–1)
TCF7L2	0.12 (0–1)	0.91 (0–1)
TNN	0.45 (0–1)	0.56 (0–1)
TP53	0.98 (0.89–1)	0.04 (0–0.24)

^aEarly means 1st, 2nd or 3rd event and late means later events.