Table 2. The relationship between 12 single nucleotide polymorphisms (SNPs) of CHI3L1 and levels of lipid parameters and YKL-40 in MONICA-10.
| SNP | Genotype distribution | Cholesterol, mmol/l | LDL, mmol/l | HDL, mmol/l | Triglyceride, mmol/l | YKL-40, ng/ml | ||||||
| All | Prevalence, n (%) | mean (SD) | p-value** | mean (SD) | p-value** | mean (SD) | p-value** | median (IQR) | p-value** | median (IQR) | p-value** | |
| rs10399931 | CC * | 1478 (57.9) | 6.2 (1.1) | 0.880 | 4.0 (1.0) | 0.811 | 1.5 (0.4) | 0.968 | 1.2 (0.9–1.7) | 0.680 | 66 (49–97) | <0.0001 |
| CT | 933 (36.6) | 6.2 (1.1) | 4.0 (1.0) | 1.4 (0.4) | 1.2 (1.0–1.8) | 47 (35–68) | ||||||
| TT | 141 (5.5) | 6.1 (1.1) | 4.0 (1.0) | 1.4 (0.4) | 1.2 (0.9–1.7) | 27 (20–40) | ||||||
| rs12123883 | TT * | 2165 (84.3) | 6.2 (1.1) | 0.609 | 4.0 (1.0) | 0.948 | 1.4 (0.4) | 0.470 | 1.2 (0.9–1.7) | 0.022 | 56 (40–84) | 0.001 |
| TC | 391 (15.2) | 6.1 (1.1) | 4.0 (1.0) | 1.5 (0.4) | 1.1 (0.9–1.6) | 58 (43–86) | ||||||
| CC | 13 (0.5) | 6.2 (1.6) | 3.8 (0.8) | 1.2 (0.4) | 1.7 (1.2–2.3) | 84 (55–233) | ||||||
| rs2486064 | GG * | 811 (31.8) | 6.2 (1.2) | 0.631 | 4.1 (1.3) | 0.760 | 1.5 (0.4) | 0.303 | 1.2 (0.9–1.6) | 0.229 | 65 (48–97) | <0.0001 |
| GA | 1247 (49.0) | 6.1 (1.1) | 4.0 (1.0) | 1.4 (0.4) | 1.2 (0.9–1.8) | 55 (39–84) | ||||||
| AA | 490 (19.2) | 6.2 (1.1) | 4.0 (1.0) | 1.5 (0.4) | 1.2 (0.9–1.7) | 44 (31–67) | ||||||
| rs2886117 | GG * | 1944 (76.9) | 6.1 (1.1) | 0.051 | 4.0 (1.0) | 0.080 | 1.4 (0.4) | 0.299 | 1.2 (0.9–1.7 | 0.524 | 54 (38–80) | <0.0001 |
| GA | 542 (21.5) | 6.2 (1.1) | 4.1 (1.1) | 1.5 (0.4) | 1.2 (0.9-1.7) | 65 (47–99) | ||||||
| AA | 41 (1.6) | 6.4 (0.9) | 4.2 (0.9) | 1.5 (0.5) | 1.1 (0.9–1.6) | 72 (51–120) | ||||||
| rs4950928 | CC * | 1592 (62.2) | 6.2 (1.1) | 0.670 | 4.0 (1.0) | 0.664 | 1.4 (0.4) | 0.865 | 1.2 (0.9–1.7) | 0.476 | 66 (49–97) | <0.0001 |
| CG | 854 (33.4) | 6.2 (1.1) | 4.0 (1.0) | 1.4 (0.4) | 1.2 (0.9–1.8) | 45 (34–64) | ||||||
| GG | 113 (4.4) | 6.2 (1.2) | 4.1 (1.0) | 1.4 (0.4) | 1.2 (1.0–1.8) | 26 (19–35) | ||||||
| rs4950930 | GG * | 2319 (90.9) | 6.2 (1.1) | 0.781 | 4.0 (1.0) | 0.814 | 1.4 (0.4) | 0.944 | 1.2 (0.9–1.7) | 0.795 | 56 (40–84) | 0.074 |
| GA | 225 (8.8) | 6.1 (1.2) | 4.1 (1.1) | 1.4 (0.4) | 1.2 (0.9–1.6) | 65 (45–93) | ||||||
| AA | 7 (0.3) | 6.4 (1.1) | 4.2 (1.1) | 1.4 (0.4) | 1.1 (1.0–3.3) | 56 (46–84) | ||||||
| rs6691378 | GG * | 2001 (78.4) | 6.1 (1.1) | 0.196 | 4.0 (1.0) | 0.305 | 1.4 (0.4) | 0.491 | 1.2 (0.9–1.7) | 0.745 | 54 (39–80) | <0.0001 |
| GA | 518 (20.3) | 6.2 (1.2) | 4.1 (1.1) | 1.5 (0.4) | 1.2 (0.9–1.7) | 66 (47–100) | ||||||
| AA | 33 (1.3) | 6.4 (0.9) | 4.1 (0.8) | 1.6 (0.5) | 1.1 (0.8–1.6) | 81 (53–120) | ||||||
| rs871799 | GG * | 2076 (81.2) | 6.2 (1.1) | 0.773 | 4.0 (1.0) | 0.936 | 1.4 (0.4) | 0.213 | 1.2 (0.9–1.7) | 0.328 | 55 (39–82) | <0.0001 |
| GC | 448 (17.5) | 6.2 (1.1) | 4.0 (1.0) | 1.5 (0.4) | 1.2 (0.9–1.6) | 64 (45–96) | ||||||
| CC | 32 (1.3) | 6.1 (1.0) | 4.0 (0.9) | 1.4 (0.3) | 1.3 (0.9–1.8) | 67 (49–110) | ||||||
| rs872129 | AA * | 2160 (84.4) | 6.1 (1.1) | 0.021 | 4.1 (1.0) | 0.238 | 1.4 (0.4) | 0.713 | 1.2 (0.9–1.7 | 0.022 | 55 (39–82) | <0.0001 |
| AG | 386 (15.1) | 6.1 (1.1) | 4.0 (1.0) | 1.5 (0.4) | 1.2 (0.8–1.7) | 64 (45–100) | ||||||
| GG | 12 (0.5) | 6.7 (1.1) | 4.5 (1.0) | 1.4 (0.3) | 1.3 (1.1–1.6) | 60 (47–112) | ||||||
| rs880633 | CC * | 734 (28.7) | 6.1 (1.1) | 0.435 | 4.0 (1.0) | 0.302 | 1.4 (0.4) | 0.243 | 1.2 (0.9–1.7) | 0.902 | 62 (47–89) | <0.0001 |
| CT | 1284 (50.3) | 6.2 (1.1) | 4.1 (1.0) | 1.4 (0.4) | 1.2 (0.9–1.7) | 56 (40–86) | ||||||
| TT | 536 (21.0) | 6.2 (1.1) | 4.1 (1.0) | 1.5 (0.4) | 1.2 (0.9–1.8) | 49 (32–75) | ||||||
| rs883125 | CC * | 1842 (71.6) | 6.2 (1.1) | 0.181 | 4.0 (1.0) | 0.072 | 1.4 (0.4) | 0.118 | 1.2 (0.9–1.7) | 0.283 | 53 (38–80) | <0.0001 |
| CG | 673 (26.2) | 6.2 (1.1) | 4.0 (1.0) | 1.5 (0.4) | 1.2 (0.9–1.7) | 64 (45–98) | ||||||
| GG | 56 (2.2) | 6.2 (1.2) | 4.0 (1.1) | 1.5 (0.5) | 1.2 (0.8–1.5) | 63 (49–86) | ||||||
| rs946263 | AA * | 1647 (64.6) | 6.2 (1.1) | 0.649 | 4.0 (1.1) | 0.714 | 1.4 (0.4) | 0.715 | 1.2 (0.9–1.7) | 0.437 | 65 (47–97) | <0.0001 |
| AG | 812 (31.8) | 6.2 (1.1) | 4.0 (1.0) | 1.4 (0.4) | 1.2 (0.9–1.8) | 45 (33–64) | ||||||
| GG | 92 (3.6) | 6.3 (1.2) | 4.2 (1.0) | 1.5 (0.4) | 1.2 (0.9–1.7) | 26 (19–36) | ||||||
*
major allele ** Linear regression models, adjusted for age and gender. All SNPs presented MAFs (minor allele frequenciy)>5%, except for rs4950930 (MAF = 4.7%)
Abbreviations: LDL, low density lipoprotein; HDL, high density lipoprotein.