Table 3. Prevalence and risk (odds ratio (95% confidence interval)) of hypercholesterolemia and low HDL at baseline according to single nucleotide polymorphisms (SNPs) of CHI3L1 in MONICA-10.
| SNP | genotype | Hypercholesterolemia | low HDL | ||
| prevalence | OR (95% CI) | prevalence | OR (95 CI) | ||
| rs10399931 | CC* | 53.2 (787/1478) | 1 | 12.2 (181/1478) | 1 |
| CT | 54.3 (507/933) | 1.05 (0.88–1.24) | 11.6 (108/933) | 0.94 (0.72–1.21) | |
| TT | 48.2 (68/141) | 0.74 (0.52–1.06) | 8.5 (12/141) | 0.66 (0.35–1.23) | |
| p = 0.394 | p = 0.176 | p = 0.408 | p = 0.374 | ||
| rs12123883 | TT * | 53.4 (1156/2165) | 1 | 11.7 (254/2165) | 1 |
| TC | 52.2 (204/391) | 1.00 (0.88–1.22) | 11.5 (45/391) | 0.97 (0.69–1.37) | |
| CC | 46.2 (6/13) | 0.70 (0.22–2.2) | 38.5 (5/13) | 4.06 (1.26–13.11) | |
| p = 0.796 | p = 0.829 | p = 0.012 | p = 0.091 | ||
| rs2486064 | GG* | 53.1 (431/811) | 1 | 11.0 (89/811) | 1 |
| GA | 53.7 (670–1247) | 1.03 (0.86–1.22) | 12.9 (161/1247) | 1.21 (0.91–1.60) | |
| AA | 52.2 (256/490) | 0.94 (0.74–1.18) | 10.6 (52/490) | 0.93 (0.64–1.34) | |
| p = 0.853 | p = 0.685 | p = 0.265 | p = 0.205 | ||
| rs2886117 | GG* | 63.4 (26/41) | 1 | 11.8 (229/1944) | 1 |
| GA | 56.3 (305–542) | 1.20 (0.98–1.46) | 12.7 (69/542) | 1.12 (0.83–1.50) | |
| AA | 52.3 (1016–1944) | 1.47 (0.76–2.85) | 4.9 (2/41) | 0.42 (1.00–1.79) | |
| p = 0.108 | p = 0.115 | p = 0.314 | p = 0.296 | ||
| rs4950928 | CC* | 53.0 (843/1592) | 1 | 11.7 (187/1592) | 1 |
| CG | 53.2 (454/854) | 1.00 (0.84–1.19) | 12.1 (103/854) | 1.06 (0.81–1.37) | |
| GG | 54.0 (61/113) | 0.91 (0.61–1.35) | 8.8 (10/113) | 0.74 (0.37–1.46) | |
| p = 0.976 | p = 0.895 | p = 0.608 | p = 0.575 | ||
| rs4950930 | GG* | 53.4 (1239/2319) | 1 | 11.8 (273/2319) | 1 |
| GA | 50.2 (113–225) | 0.86 (0.64–1.14) | 11.1 (25/225) | 0.89 (0.57–1.38) | |
| AA | 57.1 (4/7) | 1.38 (0.30–6.35) | 28.6 (2/7) | 2.41 (0.44–13.12) | |
| p = 0.640 | p = 0.507 | p = 0.368 | p = 0.538 | ||
| rs6691378 | GG* | 52.1 (1042–2001) | 1 | 11.8 (236/2001) | 1 |
| GA | 55.4 (287/518) | 1.17 (0.95–1.43) | 12.5 (65/518) | 1.10 (0.82–1.49) | |
| AA | 66.7 (22/33) | 1.75 (0.83–3.72) | 6.1 (2/33) | 0.50 (0.12–2.16) | |
| p = 0.113 | p = 0.122 | p = 0.521 | p = 0.471 | ||
| rs871799 | GG* | 52.8 (1096/2076) | 1 | 12.4 (257/2076) | 1 |
| GC | 54.7 (245/448) | 1.05 (0.85–1.30) | 10.0 (45/448) | 0.80 (0.57–1.12) | |
| CC | 43.8 (14/32) | 0.66 (0.32–1.36) | 6.3 (2/32) | 0.44 (0.10–1.89) | |
| p = 0.439 | p = 0.465 | p = 0.234 | p = 0.207 | ||
| rs872129 | AA* | 53.5 (1156/2160) | 1 | 12.5 (271/2160) | 1 |
| AG | 51.0 (197/386) | 0.91 (0.73–1.14) | 8.8 (34/386) | 0.67 (0.45–0.97) | |
| GG | 75.0 (9/12) | 2.34 (0.62–8.87) | 0 (0/12) | 0.00 (0.00-) | |
| p = 0.212 | p = 0.290 | p = 0.050 | p = 0.026 | ||
| rs880633 | CC* | 51.1 (375/734) | 1 | 12.1 (89/734) | 1 |
| CT | 54.1 (695/1284) | 1.12 (0.93–1.35) | 12.4 (159/1284 | 1.00 (0.75–1.32) | |
| TT | 53.9 (289/536) | 1.09 (0.87–1.37) | 10.1 (54/536) | 0.80 (0.56–1.16) | |
| p = 0.393 | p = 0.491 | p = 0.364 | p = 0.394 | ||
| rs883125 | CC* | 52.6 (968/1842) | 1 | 11.8 (217/1842) | 1 |
| CG | 53.9 (363/673) | 1.06 (0.88–1.27) | 12.0 (81/673) | 0.98 (0.74–1.29) | |
| GG | 60.7 (34/56) | 1.43 (0.82–2.51) | 10.7 (6/56) | 0.87 (0.36–2.10) | |
| p = 0.424 | p = 0.399 | p = 0.952 | p = 0.942 | ||
| rs946263 | AA* | 52.9 (871/1647) | 1 | 11.5 (189/1647) | 1 |
| AG | 53.8 (437/812) | 1.03 (0.86–1.22) | 12.7 (103/812) | 1.15 (0.87–1.50) | |
| GG | 58.7 (54/92) | 1.06 (0.68–1.64) | 8.7 (8/92) | 0.74 (0.35–1.58) | |
| p = 0.53 | p = 0.942 | p = 0.443 | p = 0.356 | ||
*
Major allele
Adjusted for age and gender