Figure 4. Parent-Child association for functionally enriched Gene Ontology (GO) terms among genes that were up-regulated in HAmCq^G8.

GO terms (GO consortium, version 1.2084; release date: 12:07:2011). GO terms associated with the up-regulated genes in HAmCq^G8 were considered statistically enriched if the cumulative hypergeometric p-value was <0.001 using the g: SCS threshold in g: Cocoa (http://biit.cs.ut.ee/gprofiler/gcocoa.cgi). Colored boxes represent statistically functionally enriched GO terms, while the nonsignificantly-enriched GO term is marked in white and provided to display all of the parent-child relationships in the network. Lines and/or arrows represent connections between or among different GO terms. Solid lines represent relationships between two enriched GO terms. Dashed lines represent relationships between enriched and unenriched terms or between unenriched GO terms, and are provided to connect all of the nodes on the directed acyclic graph to the main molecular function category.