Table 4. Differences in F₂-isoprostane (pg/mL) serum levels between caloric restriction (CR) and control groups at baseline (Day 0), during the intervention (Days 1 to 29), and follow-up (Days 42 and 119).

Time	N	Control diet	CR diet	p-valuea
Baseline	40	61.0 (51.8–65.0)	57.0 (40.5–79.5)	0.908
Day 1	40	55.0 (48.8–65.0)	44.0 (35.5–61.2)	0.153
Day 3	40	56.0 (46.8–73.5)	39.5 (24.8–50.2)	0.010
Day 5	40	62.5 (45.0–72.5)	33.5 (26.0–48.0)	0.002
Day 7	40	52.0 (45.0–66.0)	33.5 (23.8–45.8)	0.007
Day 14	40	50.0 (42.0–67.5)	34.0 (23.5–43.5)	0.004
Day 21	40	58.0 (49.2–60.2)	30.5 (23.8–42.5)	<0.001
Day 29	38	51.0 (49.2–53.5)	29.5 (23.2–40.8)	<0.001
Day 42	37	61.0 (55.0–65.0)	33.5 (29.0–53.5)	0.006
Day 119	34	56.0 (52.0–59.5)	56.0 (36.0–66.0)	0.692

Data are presented as median (interquartile range- IQR). CR diet, caloric restriction diet.

^aWilcoxon rank sum test for differences between Control and CR diets.