Table 3. Signal transduction mechanisms affected after overexpression of TFPIα or TFPIβ.
| GO number | Name | Whole array | TFPIα/β vs. pTOPO | P-value |
| TFPIα vs. pTOPO | ||||
| GO:0008150 | Biological process | 10463 | 137 | |
| GO:0007243 | protein kinase cascade | 321 | 11 | 0.003 |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 107 | 6 | 0.003 |
| GO:0007253 | cytoplasmic sequestering of NF-kappaB | 3 | 1 | 0.039 |
| GO:0007259 | JAK-STAT cascade | 31 | 4 | 0.001 |
| GO:0008593 | regulation of Notch signaling pathway | 3 | 1 | 0.039 |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | 605 | 1 | 0.005 |
| GO:0003674 | Molecular function | 11326 | 140 | |
| GO:0005057 | receptor signaling protein activity | 119 | 6 | 0.004 |
| GO:0005006 | epidermal growth factor receptor activity | 2 | 1 | 0.025 |
| GO:0004694 | eukaryotic translation initiation factor 2α kinase activity | 3 | 1 | 0.037 |
| GO:0004710 | MAP/ERK kinase kinase activity | 1 | 1 | 0.012 |
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | 3 | 1 | 0.037 |
| GO:0005093 | Rab GDP-dissociation inhibitor activity | 2 | 1 | 0.025 |
| GO:0003924 | GTPase activity | 144 | 5 | 0.033 |
| TFPIβ vs. pTOPO | ||||
| GO:0008150 | Biological process | 10463 | 435 | |
| GO:0007242 | intracellular signaling cascade | 1142 | 63 | 0.018 |
| GO:0042504 | tyrosine phosphorylation of Stat4 protein | 1 | 1 | 0.042 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | 25 | 5 | 0.003 |
| GO:0016601 | Rac protein signal transduction | 9 | 3 | 0.005 |
| GO:0034097 | response to cytokine stimulus | 3 | 2 | 0.005 |
| GO:0030522 | intracellular receptor-mediated signaling pathway | 48 | 5 | 0.048 |
| GO:0030518 | steroid hormone receptor signaling pathway | 42 | 5 | 0.029 |
| GO:0030521 | androgen receptor signaling pathway | 28 | 4 | 0.027 |
| GO:0003674 | Molecular function | 11326 | 482 | |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 55 | 7 | 0.008 |
| GO:0004710 | MAP/ERK kinase kinase activity | 1 | 1 | 0.043 |
| GO:0008427 | calcium-dependent protein kinase inhibitor activity | 1 | 1 | 0.043 |
| GO:0008083 | growth factor activity | 123 | 10 | 0.041 |
| GO:0005006 | epidermal growth factor receptor activity | 2 | 2 | 0.002 |
The differentially expressed mRNAs were loaded into eGOn for functional annotation, and the Master-Target test was used to identify significantly over-represented gene ontology categories (by comparing the number of genes associated with a gene ontology category to the total number of genes in the array associated with that category).