Table 4. Clinical relevance of gene signatures following overexpression of TFPIα or TFPIβ.

Clinical Variable	TFPIα	TFPIβ
Merged Breast cancer datasets (n = 545)	P-value	P-value
Age	ns	4.96×10−5
Tumor size	ns	Ns
Tumor grade	4.87×10−4	2.41×10−14
ER status	1.09×10−8	2.04×10−60
Relapse-free survival time	ns	8.33×10−4
Relapse-free survival	ns	4.09×10−4

Three publicly available, clinically annotated breast cancer datasets (GSE6532, GSE4922, and GSE7390) were downloaded from the Gene Expression Omnibus (GEO) database at NCBI and merged. Associations between the differentially expressed genes and clinical variables were evaluated using the globaltest package in R.