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. 2012 Oct 5;7(10):e46989. doi: 10.1371/journal.pone.0046989

Figure 6. Other type-II activating products stimulate IL-4 production by macrophages.

Figure 6

IFN-γ-primed BMMφ (105/well) from WT BALB/c (a) or C57BL/6 (b) mice were stimulated with LPS (10 ng/ml) in the presence or absence of opsonized SRBC (IC), glatiramer acetate (200 ng/ml), SEA (5 µg/ml) or SEA opsonized with IgG purified from infected mice (SEA:IgG) or control IgG (SEA:CIgG; 5 µg/ml: 20 µg/ml) for 24 hours. Cytokine production was measured in culture supernatants by ELISA. Shown are the means and SEM of triplicate wells from 1 of 2 representative experiments. *p<0.05 compared to LPS alone and **p<0.001 compared to al other groups by one-way ANOVA with Bonferroni’s post test. ***p<0.05 compared to medium by Dunnett’s Multiple Comparison Test.