Fig. 3.

Focal microgliosis in young affected DJ1-C57 mice. (A) Representative midbrain sections stained for CV in young WT and DJ1-C57 affected mice (1000× magnification). Thin arrows denote typical morphology of DA neurons of the SNc; thick arrows denote shrunken, dead nuclei; and arrowheads denote appearance of cells with altered morphology. (B) CD11b staining in the midbrain of young WT (Left) and DJ1-C57 affected (Right) mice was quantified and represented as the number of Cd11b-positive cells in the MTN region of the SNc. WT and DJ1-C57 affected are represented by blue and red bars, respectively. Side A is depicted as solid shading and side B as hatched shading. NS, not significant (P > 0.05); *P < 0.05; ANOVA, followed by Tukey’s LSD post hoc tests. Data are represented as means (n = 3–9 per group) ± SEM.