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DJ1-C57 preclinical model of DA neurodegeneration. (A) Altered representative micrographs reproduced with permission from the Mouse Brain Library [www.mbl.org; Rosen et al. (36)] depicting healthy (red) SNc, striatum, and LC in 6-wk-old DJ1-C57 mice or all WT groups examined. (B) Affected DJ1-C57 mice demonstrate unilateral DA cell loss in the SNc but not in the LC. (C) Aged DJ1-C57 mice exhibit widespread degeneration in their nigrostriatal tract, as well as their LC.
