Abstract
An approximate, new model for the structure of the periodic, undulated Pβ′, phase of phosphatidylcholine bilayers is proposed. The properties of this phase are deduced by minimizing a Landau-de Gennes expression for the bilayer free energy when this free energy contains a term favoring a spontaneous curvature of the membrane. The theoretical calculation leads to a model for the Pβ′ phase of phosphatidylcholine bilayers having a number of novel physical properties, including periodic variations in membrane “fluidity.”
Keywords: Landau-de Gennes theory, spontaneous curvature, Pβ′-phase, phase transitions
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Selected References
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- Copeland B. R., McConnel H. M. The rippled structure in bilayer membranes of phosphatidylcholine and binary mixtures of phosphatidylcholine and cholesterol. Biochim Biophys Acta. 1980 Jun 20;599(1):95–109. doi: 10.1016/0005-2736(80)90059-0. [DOI] [PubMed] [Google Scholar]
- Gebhardt C., Gruler H., Sackmann E. On domain structure and local curvature in lipid bilayers and biological membranes. Z Naturforsch C. 1977 Jul-Aug;32(7-8):581–596. doi: 10.1515/znc-1977-7-817. [DOI] [PubMed] [Google Scholar]
- Hafeman D. G., von Tscharner V., McConnell H. M. Specific antibody-dependent interactions between macrophages and lipid haptens in planar lipid monolayers. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4552–4556. doi: 10.1073/pnas.78.7.4552. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Helfrich W. Elastic properties of lipid bilayers: theory and possible experiments. Z Naturforsch C. 1973 Nov-Dec;28(11):693–703. doi: 10.1515/znc-1973-11-1209. [DOI] [PubMed] [Google Scholar]
- Janiak M. J., Small D. M., Shipley G. G. Nature of the Thermal pretransition of synthetic phospholipids: dimyristolyl- and dipalmitoyllecithin. Biochemistry. 1976 Oct 19;15(21):4575–4580. doi: 10.1021/bi00666a005. [DOI] [PubMed] [Google Scholar]
- Janiak M. J., Small D. M., Shipley G. G. Temperature and compositional dependence of the structure of hydrated dimyristoyl lecithin. J Biol Chem. 1979 Jul 10;254(13):6068–6078. [PubMed] [Google Scholar]
- Krbecek R., Gebhardt C., Gruler H., Sackmann E. Three dimensional microscopic surface profiles of membranes reconstructed from freeze etching electrol micrographs. Biochim Biophys Acta. 1979 Jun 13;554(1):1–22. doi: 10.1016/0005-2736(79)90002-6. [DOI] [PubMed] [Google Scholar]
- Luna E. J., McConnell H. M. The intermediate monoclinic phase of phosphatidylcholines. Biochim Biophys Acta. 1977 May 2;466(3):381–392. doi: 10.1016/0005-2736(77)90331-5. [DOI] [PubMed] [Google Scholar]
- Mabrey S., Sturtevant J. M. Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry. Proc Natl Acad Sci U S A. 1976 Nov;73(11):3862–3866. doi: 10.1073/pnas.73.11.3862. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owicki J. C., McConnell H. M. Lateral diffusion in inhomogeneous membranes. Model membranes containing cholesterol. Biophys J. 1980 Jun;30(3):383–397. doi: 10.1016/S0006-3495(80)85103-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owicki J. C., McConnell H. M. Theory of protein-lipid and protein-protein interactions in bilayer membranes. Proc Natl Acad Sci U S A. 1979 Oct;76(10):4750–4754. doi: 10.1073/pnas.76.10.4750. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Owicki J. C., Springgate M. W., McConnell H. M. Theoretical study of protein--lipid interactions in bilayer membranes. Proc Natl Acad Sci U S A. 1978 Apr;75(4):1616–1619. doi: 10.1073/pnas.75.4.1616. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silvius J. R., Read B. D., McElhaney R. N. Thermotropic phase transitions of phosphatidylcholines with odd-numbered n-acyl chains. Biochim Biophys Acta. 1979 Jul 19;555(1):175–178. doi: 10.1016/0005-2736(79)90081-6. [DOI] [PubMed] [Google Scholar]
- Stamatoff J. B., Graddick W. F., Powers L., Moncton D. E. Direct observation of the hydrocarbon chain tilt angle in phospholipid bilayers. Biophys J. 1979 Feb;25(2 Pt 1):253–261. doi: 10.1016/s0006-3495(79)85289-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tardieu A., Luzzati V., Reman F. C. Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases. J Mol Biol. 1973 Apr 25;75(4):711–733. doi: 10.1016/0022-2836(73)90303-3. [DOI] [PubMed] [Google Scholar]
- Ververgaert P. H., Verkleij A. J., Elbers P. F., van Deenen L. L. Analysis of the crystallization process in lecithin liposomes: a freeze-etch study. Biochim Biophys Acta. 1973 Jul 6;311(3):320–329. doi: 10.1016/0005-2736(73)90313-1. [DOI] [PubMed] [Google Scholar]
- Wittebort R. J., Schmidt C. F., Griffin R. G. Solid-state carbon-13 nuclear magnetic resonance of the lecithin gel to liquid-crystalline phase transition. Biochemistry. 1981 Jul 7;20(14):4223–4228. doi: 10.1021/bi00517a042. [DOI] [PubMed] [Google Scholar]
- von Tscharner V., McConnell H. M. An alternative view of phospholipid phase behavior at the air-water interface. Microscope and film balance studies. Biophys J. 1981 Nov;36(2):409–419. doi: 10.1016/S0006-3495(81)84740-6. [DOI] [PMC free article] [PubMed] [Google Scholar]