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The free energy at folding temperature in one dimension as a function of fraction of native contacts Q and in two dimension as a function of Q and energy. Free-energy profile, at folding temperature Tf, as a function of Q for (A) three (of 13) proteins with different sizes and (B) three (of nine) proteins with the same size. (C) Two-dimensional free-energy profile for CI2 as a function of Q and energy at Tf normalized by the corresponding kBTf.
