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Generation rate as a function of the ratio of the continuous lipid flow to the dispersed N2 flow, ϕ = QL/QG. Decreasing ϕ quickens the generation rate for high continuous phase flows. Dual-layer microbubbles accumulate at rates in excess of 5 × 104 Hz in the 4-channel arrangement and in excess of 105 Hz in the 8-channel for very low values of ϕ and high QL.
