Table 1.
Cell lineage | Marker | Stage of development | |||||
---|---|---|---|---|---|---|---|
D3CM | D4EBL | D4EXPBL | D5BL | D6BL | D7BL | ||
Inside/ICM/Epi | Oct-4 | +++ | ++++ | ++ | +++ | +++ | ++ |
Cdx-2 | − | − | − | − | − | − | |
H4K5ac | ++++ | ++ | ++ | ++ | ++++ | ++++ | |
Outside/TE | Oct-4 | +++ | ++ | ++ | + | +/− | +/− |
Cdx-2 | − | +/− | +++ | ++++ | +++++ | +++++ | |
H4K5ac | ++++ | ++++ | ++++ | ++++ | ++++ | ++++ |
++++ = ; +++ = ; ++ = ; +/− = ; − =.
Epi = epiblast; ICM = inner cell mass; TE = trophectoderm; D3CM = day-3 compact morulae; D4EBL = day-4 early blastocysts; D4EXPBL = day-4 expanded blastocysts; D5BL = day-5 blastocysts; D6BL = day-6 blastocysts; D7BL = day-7 blastocysts.