A high throughput screen identifies three inhibitors of TAg ATPase activity. A. The indicated compounds were tested in triplicate at a final concentration of 100 μM in a steady state ATPase assay and the data plotted relative to the DMSO control, which is set at “100.” B. The structures of bithionol and hexachlorophene are shown. C. Results from triplicate steady state ATPase assays are shown, +/− SD, for bithionol, grey bars, and hexachlorophene, black bars, at the indicated concentrations. Data were again plotted relative to the DMSO control, which was set at “100.”