Skip to main content
. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Antiviral Res. 2012 Aug 7;96(1):70–81. doi: 10.1016/j.antiviral.2012.07.012

Figure 6.

Figure 6

Both bithionol and hexachlorophene inhibit BKV DNA replication in Vero monkey kidney cells. A. The replication of BKV DNA was assessed after 5 d of infection with MAL2-11B, cidofovir, bithionol or hexachlorophene, and the levels of viral DNA were quantified by qPCR as described in the Materials and methods. The data were standardized to the DMSO control, which is set to “100” +/− SE. Data represent the means of 12 experiments from four independent infections. Please note that MAL2-11B was used at a final concentration of 100 μM and cidofovir at 350 μM, whereas bithionol and hexachlorophene were used at a final concentration of 10 or 30 μM. B. The combination of bithionol and cidofovir does not further inhibit SV40 DNA replication in CV1 monkey kidney cells. Replication of viral DNA was quantified by qPCR as described in the Materials and methods. The data represent the means of 8 independent experiments, +/− SE. Each compound was tested as indicated at a final concentration of 10 μM. The combination of 10 μM bithionol and 10 μM cidofovir was not significantly different from the effect of 10 μM cidofovir alone.