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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Antiviral Res. 2012 Aug 7;96(1):70–81. doi: 10.1016/j.antiviral.2012.07.012

Table 1.

Bithionol and hexachlorophene affect the Km for ATP in TAg. Kinetic parameters (Km and Vmax) were determined by Lineweaver-Burk analysis of TAg in the presence of 150 μM ADP or 3 μM bithionol or hexachlorophene over a range of ATP concentrations, as shown in Figure 4. ANCOVA was used to determine the p values for each pair-wise comparison.

Km (μM) Vmax (pmol/min)
TAg + DMSO 110 3.5
TAg + ADP 200** 2.9‡
TAg + Bithionol 590** 10‡
TAg + Hexachlorophene 290* 6.6‡

TAg + DMSO versus TAg + ADP or bithionol,

**

p<0.01;

TAg + DMSO versus TAg + hexachlorophene,

*

p<0.05;

TAg + DMSO versus TAg + ADP, bithionol or hexachlorophene,

‡

p>0.5