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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Nucl Med Biol. 2012 Jun 30;39(8):1105–1116. doi: 10.1016/j.nucmedbio.2012.05.011

Scheme 1.

Scheme 1

aReaction conditions and reagents: (a) K2CO3, BnBr, TBAI, acetone, refl., 68%; (b) NaH, BnBr, TBAI, DMF, −10 °C – RT; (c) BH3•SMe2 in THF, 55 °C, then NaOH/H2O2, 0 °C, 44%; (d) MsCl, TEA, CH2Cl2, 0 °C-RT, 2 h, 91%; (e) n-Bu4NF•3H2O, 150 °C, 30 min, 77%; (f) Pd/C, H2, rt, 16 h, 90%. Radiolabeling conditions: (e) n-Bu4N[18F]F, TBAOMs, 180 °C, 30 min; (f) TMSI, CH3CN, 130 °C, 5 min.