Table 2.
Demographic and clinical variables for CRC patients
| Variables | Training Set (N=435)
|
Replication Set (N=227)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Recurrence | No recurrence | P Value | Dead | Alive | P value | Recurrence | No recurrence | P value | Dead | Alive | P value | |
| Age, mean (SD) | 59.2 (13.7) | 58.4 (12.8) | 0.6 | 62.3(13.3) | 57.9 (12.8) | 0.01 | 57.06(12.30) | 53.00(16.28) | 0.23 | 56.77(12.26) | 56.86(13.00) | 0.95 |
| Smoking pack-years (SD) | 37.4(36.9) | 30.8(39.3) | 0.33 | 37.2 (36.4) | 31.4(39.2) | 0.47 | 27.30(20.74) | 22.70(15.12) | 0.63 | 25.30(21.68) | 30.20(21.05) | 0.29 |
| Gender, N (%) | ||||||||||||
| Male | 57(61.3) | 206(60.2) | 41(63.1) | 222(60.0) | 124(58.8) | 7(46.7) | 72(58.1) | 60(58.3) | ||||
| Female | 36(38.7) | 136(39.8) | 0.85 | 24(36.9) | 148(40.0) | 0.64 | 87(41.2) | 8(53.3) | 0.36 | 52(41.9) | 43(41.7) | 0.98 |
| Race, N (%) | ||||||||||||
| Caucasian | 73(78.5) | 279(81.8) | 51(78.5) | 301(81.6) | 179(84.8) | 12(80.0) | 105(84.7) | 87(84.5) | ||||
| African-American | 9(9.7) | 33(9.7) | 7(10.8) | 35(9.5) | 11(5.2) | 1(6.7) | 7(5.6) | 5(4.9) | ||||
| Others | 11(11.8) | 29(8.5) | 0.61 | 7(10.8) | 33(8.9) | 0.84 | 21(10.0) | 2(13.3) | 0.88 | 12(9.7) | 11(10.7) | 0.94 |
| Tumor location, N (%) | ||||||||||||
| Proximal | 21(23.3) | 100(29.4) | 14(22.6) | 107(29.1) | 64(32.0) | 3(20.0) | 40(35.1) | 27(26.5) | ||||
| Distal | 20(22.2) | 80(23.5) | 17(27.4) | 83(22.6) | 70(35.0) | 8(53.3) | 40(35.1) | 39(38.2) | ||||
| Rectal | 49(54.4) | 160(47.1) | 0.41 | 31(50.0) | 178(48.4) | 0.51 | 66(33.0) | 4(26.7) | 0.35 | 34(29.8) | 36(35.3) | 0.38 |
| Stage, N (%) | ||||||||||||
| Stage I | 4(4.3) | 57(16.7) | 2(3.1) | 59(15.9) | 27(12.8) | 0(0.0) | 15(12.1) | 12(11.7) | ||||
| Stage II | 36(38.7) | 135(39.5) | 26(40.0) | 145(39.2) | 78(37.0) | 9(60.0) | 43(34.7) | 45(43.7) | ||||
| Stage III | 53(57.0) | 150(43.9) | 0.005 | 37(56.9) | 166(44.9) | 0.02 | 106(50.2) | 6(40.0) | 0.13 | 66(53.2) | 46(44.7) | 0.36 |
| Histology grade, N (%) | ||||||||||||
| Well-differentiated | 4(4.4) | 11(3.3) | 3(4.8) | 12(3.3) | 8(3.9) | 0(0.0) | 5(4.2) | 3(3.0) | ||||
| Moderate-differentiated | 73(80.2) | 283(84.2) | 49(77.8) | 307(84.3) | 159(77.9) | 11(78.6) | 88(74.6) | 83(82.2) | ||||
| Poorly-differentiated | 14(15.4) | 42(12.5) | 0.65 | 11(17.5) | 45(12.4) | 0.43 | 37(18.1) | 3(21.4) | 0.73 | 25(21.2) | 15(14.9) | 0.40 |