Table 2.
Parameters estimated from fits of the Hill equation to inhibition curves.
| GABA | Ginkgolide A |
Ginkgolide B |
Ginkgolide C |
||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 (μM) | nH | n | IC50 (μM) | nH | n | IC50 (μM) | nH | n | |
| 0.5 μM | 5.74 ± 0.17 | −0.99 ± 0.08 | 5 | 0.75 ± 0.07 | −0.87 ± 0.05 | 6 | 0.83 ± 0.11 | −0.75 ± 0.04 | 5 |
| 1.2 μM | 42.3 ± 5.76 | −0.82 ± 0.07 | 6 | 2.37 ± 0.22 | −0.97 ± 0.07 | 7 | 5.39 ± 0.59 | −1.04 ± 0.14 | 7 |
| 3.0 μM | 181.6 ± 12.6 | −0.61 ± 0.03 | 5 | 5.72 ± 0.63 | −0.78 ± 0.06 | 5 | 22.0 ± 2.71 | −0.81 ± 0.05 | 5 |
| 10 μM | 873.7 ± 108.4 | −0.73 ± 0.04 | 5 | 129.3 ± 21.6 | −0.83 ± 0.06 | 7 | 519.8 ± 115.1 | −0.83 ± 0.05 | 4 |
IC50 is the concentration that inhibits 50% of responses, nH is the Hill coefficient and n is the number of oocytes from which data was collected. Data are the mean ± S.E.M.