. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Addict Biol. 2012 Jun 28;18(6):10.1111/j.1369-1600.2012.00461.x. doi: 10.1111/j.1369-1600.2012.00461.x

Table 2.

Subjective ratings of physical symptoms, mood and drug effect

		Placebo		Quetiapine
		MJ	Withdrawal	MJ	Withdrawal
Physical Symptoms	Nauseated	18.5 (9.4)	24.1 (6.9)	15.0 (7.1)	9.9 (1.9)^*
	Stomach Pain	17.6 (8.4)	23.1 (6.5)	8.7 (3.8)	7.5 (1.4)^**
	Upset Stomach	18.4 (8.6)	29.4 (7.6)	9.4 (5.1)	8.3 (2.3)^***
	Muscle Pain	7.2 (5.4)	19.8 (6.1)	10.7 (5.5)	6.3 (2.5)^*
Mood & Drug Effect	Good Effect	64.1 (10.1)	23.6 (6.6)^###	75.9 (6.6)	19.8 (8.1)
	High	72.0 (7.3)	15.5 (5.5)^###	81.7 (4.2)	13.0 (8.1)
	Mellow	65.9 (8.0)	46.8 (6.6)^#	69.4 (6.0)	53.5 (6.9)

Representative peak (mean ± SEM) subjective ratings of physical symptoms, mood, and drug effect during experimenter-administered marijuana (MJ) smoking (6.2% THC) and during withdrawal as a function of placebo and quetiapine administration. Participants rated each effect on a 100 mm line (0 mm = ‘not at all’; 100 mm = ‘extremely’). Significant difference between the marijuana and withdrawal conditions under placebo quetiapine indicated by

= p ≤ 0.05,

^##

= p ≤ 0.01,

^###

= p ≤ 0.001.

Significant differences between placebo and quetiapine indicated by

= p ≤ 0.05;

^**

= p ≤ 0.01;

^***

= p ≤ 0.001.