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. Author manuscript; available in PMC: 2012 Oct 7.
Published in final edited form as: Nat Struct Mol Biol. 2012 Jun 17;19(7):719–721. doi: 10.1038/nsmb.2327

Figure 2.

Figure 2

CLIP-tag density of splicing factors relative to the closest branchpoint. (a–d) Published alignments of cross-linking and immunoprecipitation (CLIP) tags were overlapped with lariat introns from four separate studies of human splicing factors: FOX2 in human embryonic stem cells14 (a); PTB13 (b) and hnRNP C12 in HeLa cells (c); and hnRNP A2/B1, hnRNP F and hnRNP U in 293 cells15 (d). The genomic coordinates of tag alignments were converted to distance from branchpoints. Tag density (y axis) is plotted along this branchpoint coordinate system (x axis) for three regulators of splicing. The branchpoint is located at x-axis position zero.