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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Int J Cancer. 2011 Apr 25;130(3):509–520. doi: 10.1002/ijc.26005

Figure 3. Ectopic expression of MKK4 suppresses metastatic colonization of AT6.1 prostate cancer cells in an experimental metastasis assay.

Figure 3

A. Schematic of the results from an experimental metastasis assay in which 1×104 cells are injected intravenously via tail vein venopuncture. B. Box plot of the number of overt surface lung lesions present in mice injected with either AT6.1-Vector or AT6.1-HA-MKK4 cells via experimental metastases assay. Boundaries of box are 25th and 75th percentiles, with solid line indicating median, dashed line indicating mean, whiskers indicating 10th and 90th percentiles. The mean (± standard error of the mean) number of overt metastases AT6.1-Vector was 54.9 ± 6.0 as compared to 6.8 ± 1.6 for AT6.1-HA-cells (p<0.001). C. Representative gross pathology of lungs harvested from mice 28 dpi of either AT6.1-Vector or AT6.1-HA-MKK4 cells. D. Kaplan-Meier survival analyses showed that the median survival for AT6.1 Vector animals was 28 days vs. 42 days for AT6.1-HA-MKK4 animals (p<0.0001).