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. 2012 Oct 1;26(19):2119–2137. doi: 10.1101/gad.200303.112

Figure 1.

Figure 1.

Comparison of select CTD sequences. The CTD sequences of fission and budding yeast, zebrafish, and humans are shown and aligned to display the context of the heptad repeats. All-consensus YSPTSPS repeats heptads are in red, and the numbers next to the parentheses indicate the repeat number. The CTD of fission yeast contains 29 heptads, 24 of which are all-consensus, whereas the CTD of budding yeast consists of 26 heptads, 19 of which are perfect consensus. The fish and human CTDs each consist of 52 repeats, with a 10- to 11-residue motif (in bold) at the very C terminus. Highlighting the conservation of the CTD among vertebrates, fish and human CTDs are 97% identical. Residues in the fish CTD that differ from humans are in yellow, and human residues that deviate from the consensus are in blue.