Table 1.
Frequency of new medical problems in healthy male and female volunteers.
| Male | Female | Total (% of all screened) | |
|---|---|---|---|
| All volunteers screened | 504 | 483 | 987 (99.7) |
| New diagnoses | 14 | 9 | 23 (2.4) |
| Median age at new diagnosis (IQR)* | 32.2 (22.1–32.2) | 25.4 (20.7–34.4) | 30.0 (21.2–37.5) |
| Age group† | |||
| 18–29 | 5/341 | 6/338 | – |
| 30–40 | 6/111 | 2/100 | – |
| 41–65 | 3/52 | 1/45 | – |
| Alcohol excess with abnormal LFTs | 2 | 0 | 2 (0.2) |
| Nephrotic syndrome | 1 | 0 | 1 (0.1) |
| Hypercholesterolemia | 2 | 0 | 2 (0.2) |
| Hemoglobinopathy | 0 | 4 | 4 (0.4) |
| Iron deficiency anemia‡ | 0 | 2 | 2 (0.2) |
| Chronic hepatitis B | 1 | 0 | 1 (0.1) |
| Chronic hepatitis C | 2 | 0 | 2 (0.2) |
| Hypertension | 4 | 1 | 5 (0.5) |
| Cardiac murmur requiring investigation | 1 | 1 | 2 (0.2) |
| Supraclavicular mass | 0 | 1 | 1 (0.1) |
| Allergic skin rash with eosinophilia | 1 | 0 | 1 (0.1) |
| Tungiasis | 1 | 0 | 1 (0.1) |
More than one abnormality may coexist in a single participant. LFTs = liver function tests.*IQR = interquartile range, Mann‐Whitney p= 0.27.†Chi‐square for trend with age p= 0.02 males, p= 0.82 females.‡Considered clinically significant in males or postmenopausal females, or in any volunteer if Hb < 10 g/dL.