Table 1.

Genes Catalogued in the AD&FTLD and PD Mutation Databases

Primary disease	Gene	Genomic location	Mutations (clinical/unclear/ benign coding)	Unrelated individuals or families	Referencesa
AD	APP	21q21.2	32/1/6	90	86
	PSEN1	14q24.3	185/8/4	411	217
	PSEN2	1q42.13	13/7/5	34	39
FTLD	C9orf72	9p21.2	1/0/0	336	5
	CHMP2B	3p11.2	4/4/4	12	11
	FUS	16p11.2	23/4/18	54	15
	GRN	17q21.32	69/35/45	264	89
	MAPT	17q21.1	44/2/27	138	172
	TARDBP	1p36.22	34/2/9	95	26
	VCP	9p13.3	17/2/0	45	26
PD	LRRK2	12q12	6/68/54	1,051	176
	PARK2	6q26	127/65/22	777	164
	PARK7	1p36.23	6/17/5	31	26
	PINK1	1p36	28/80/30	190	69
	SNCA	4q22.1	25/1/1	51	49
Total	14		614/296/230	3,579	1,127

^aJournal article or personal communication.