Figure 1.

Plasma glucose concentration curve during intraperitoneal glucose tolerance test (IPGTT) for C57Bl/6J mice fed a normal or high-fat-containing diet with or without ilepatril, candoxatril, or enalapril for 12 weeks (prevention protocol). Data are the mean ± SEM in mM. Fasting basal blood glucose levels were 121 ± 8, 143 ± 9, 138 ± 4, 175 ± 5, and 116 ± 7 mg/dL for control, high fat, high fat + ilepatril, high fat + candoxatril, and high fat + enalapril, respectively. Control (closed circles), high fat (open circles), high fat + ilepatril (closed innervated triangle), high fat + candoxatril (open triangle), and high fat + enalapril (closed rectangle). The area under the curve (AUC) was significantly different P < 0.01 for high-fat-fed mice versus control and high-fat-fed mice treated with candoxatril versus control. There was no significant difference for AUC between mice fed a high-fat diet containing ilepatril or enalapril versus control. The number of mice in each group was the same as shown in Table 1.