Figure 6.

Sensory nerve conduction velocity, thermal nociception, and intraepidermal nerve fiber profiles for NEP^−/− mice fed a normal or high-fat-containing diet with or without ilepatril, candoxatril, or enalapril for 12 weeks (prevention protocol). Control (open bar), high fat (right hatch bar), high fat + ilepatril (left hatch bar), high fat + candoxatril (cross hatch bar), and high fat + enalapril (closed bar). Data are the mean ± SEM. The number of mice in each group was the same as shown in Table 1. a, P < 0.05 versus control; b, P < 0.05 versus high-fat-fed mice.