Table 1.
Determination | Control | High fat | High fat + ilepatril | High fat + candoxatril | High fat + enalapril |
---|---|---|---|---|---|
C57Bl/6 mice | (12) | (11) | (12) | (12) | (10) |
| |||||
Start body weight (g) | 27.5 ± 0.4 | 26.7 ± 0.5 | 27.2 ± 0.6 | 26.3 ± 0.5 | 27.0 ± 0.5 |
End body weight (g) | 32.2 ± 0.6 | 42.9 ± 1.4a | 29.0 ± 0.9b,c | 45.3 ± 0.7a | 29.3 ± 0.5b,c |
Blood glucose (mg/dL) | 188 ± 7 | 183 ± 8 | 152 ± 8 | 214 ± 19 | 177 ± 10 |
Epididymal fat pad (g) | 0.31 ± 0.05 | 0.95 ± 0.08a | 0.29 ± 0.05b,c | 1.13 ± 0.08a | 0.16 ± 0.02b,c |
Fat pad/final body weight (%) | 0.95 ± 0.14 | 2.21 ± 0.18a | 0.98 ± 0.15b,c | 2.52 ± 0.21a | 0.54 ± 0.07b,c |
| |||||
NEP−/− mice | (12) | (16) | (12) | (14) | (14) |
| |||||
Start body weight (g) | 24.5 ± 0.6 | 25.6 ± 0.4 | 24.2 ± 0.6 | 25.1 ± 0.9 | 25.7 ± 0.5 |
End body weight (g) | 29.1 ± 0.6 | 42.1 ± 1.3a | 27.1 ± 1.1b,c | 43.8 ± 2.1a | 27.3 ± 0.8b,c |
Blood glucose (mg/dL) | 139 ± 8 | 153 ± 8 | 148 ± 10 | 173 ± 12 | 163 ± 6 |
Epididymal fat pad (g) | 0.24 ± 0.03 | 1.09 ± 0.06a | 0.19 ± 0.02b,c | 0.90 ± 0.04a | 0.21 ± 0.06b,c |
Fat pad/final body weight (%) | 0.80 ± 0.09 | 2.62 ± 0.13a | 0.70 ± 0.07b,c | 2.13 ± 0.15a | 0.60 ± 0.05b,c |
Data are presented as the mean ± SEM. aP < 0.05 compared to control; bP < 0.05 compared to high fat; cP < 0.05 compared to candoxatril. Parentheses indicate the number of experimental animals in each group.